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The Power of the Lion's Mane Mushroom: Regenerate Your Brain With Lion's Mane

The Power of Lion’s Mane Mushroom

 

Ward W. Bond, PhD

Ken Babal, CN

 

Disclaimer: Every effort has been made to ensure that the information contained in this book is complete and accurate. However, neither the publisher nor the author is engaged in rendering professional advice or services to the individual reader. The ideas, treatments, medications, procedures, and other suggestions contained in this book are not intended as a substitute for consulting with your physician. All matters regarding your physical health require medical supervision. Neither the author(s) nor the publisher shall be liable or responsible for any loss, injury, or damage allegedly arising from any information or suggestion in this book.

 

For information contact:

800.620.9975

 

Copyright 2012 by Ward W. Bond, PhD and Ken Babal, CN

All rights reserved. No portion of this book may be reproduced or transmitted electronically without authorized consent of the author(s).

 

ISBN

Library of Congress Cataloging-in-Publication Data

 

Printed in the United States of America

 

REGENERATE YOUR BRAIN WITH LION’S MANE

I. Medicinal Value of Mushrooms

II. Lion’s Mane: The Brain Regenerator

III. Nerve Growth Factor

IV. Amyloid Beta-Peptide

V. Alzheimer’s Disease and Other Types of Dementia

VI. Anti-Dementia Studies

VII. Cognitive Studies

VIII. Depression and Anxiety

IX. Sleep Apnea and Snoring

X. Case Studies

XI. Summary

References

I. Medicinal Value of Mushrooms

For thousands of years, people have consumed mushrooms such as Reishi, Tremella, Cordyceps and others to maintain and improve health, preserve youth, and increase longevity. In ancient China and Japan, these mushrooms were highly valued and reserved only for emperors or royal families. Reishi is called the “mushroom of immortality” and has been consumed in China for 2,000 years to improve the capacity of the mind and memory. It is said to be a supreme “shen” (spiritual) tonic that invokes peacefulness, strengthens nerves and changes how we perceive life. Shiitake is also highly regarded and is said to boost chi, our protective energy. In Japanese herbal medicine (kampo), maitake is used as a treatment for a variety of conditions and as a tonic to strengthen the body and improve overall health. Lion’s Mane, an edible mushroom widely distributed in Japan and China, is reputed to have many health benefits including that of a nervous system tonic. In traditional Chinese medicine, these and other mushrooms are regarded as the highest of tonics, used singly and as ingredients in classic herbal formulations in which they are considered the principle ingredient or “emperor.”

In the United States, mushrooms are sometimes viewed with suspicion because of certain poisonous or hallucinogenic types. This reputation, however, is rapidly changing as mushroom extracts become popular in holistic medicine and as dietary supplements. In natural food and supplement stores, they are carving out their own niche apart from vitamins and botanicals. Being neither plant nor animal, but members of the fungal family, they possess unique characteristics that confer a broad array of health benefits.

The medicinal properties of mushrooms have been documented for centuries in traditional Chinese medicine. Studies on the bioactive constituents and pharmacology of mushrooms were started in the late 1960s, and have attracted much attention since the early 1980s. In numerous experiments and clinical trials, they have demonstrated antiallergenic, antibacterial, anti-inflammatory and antiviral actions, as well as an ability to sensitize cells to insulin. A common property of the mushrooms is their outstanding ability to activate cellular immunity. For this purpose, they are among the most effective substances, drug or natural product. Based on studies appearing in peer-reviewed medical journals, mushroom extracts are crossing over into mainstream medicine as adjunct treatments for cancer patients. You might be surprised to learn that a best-selling anticancer drug in Europe and Asia, known as PSK, is a mushroom extract. Other mushroom extracts have since shown greater potential for anti-tumor activity. Maitake D-Fraction®, for example, is a highly researched extract containing a proteoglucan shown to activate anticancer genes and vital components of cellular immunity.1 In a clinical trial with patients suffering from various types of advanced cancers, Maitake D-Fraction® induced tumor regression and improved overall symptoms.2

Maitake mushroom is also the source of another extract that has demonstrated an ability to sensitize cells to the effects of insulin. Maitake SX-Fraction® contains a glycoprotein that has helped diabetics reduce their fasting blood glucose, triglycerides, insulin and body weight.3

II. Lion’s Mane: The Brain Regenerator

Lion’s Mane (Hericium erinaceus), or yamabushitake, is a unique mushroom for maintaining brain health and improving cognitive functions. It’s not surprising that a mushroom would surpass plant foods in this regard. Mushrooms differ from plants in that they grow faster at night. Because they contain no chlorophyll, they cannot manufacture food energy from the sun. Instead of calories from solar energy, they are said to provide lunar energy, which is believed to nourish the brain with intuition and imagination.

Lion’s Mane is one of the edible mushrooms widely distributed in Japan and China. Its name comes from its beautiful white icicle-like spines. One variety of the mushroom is marketed as a remedy for gastric and duodenal ulcers and chronic gastritis. In traditional Chinese medicine, Lion’s Mane is used to promote strength, vigor and good digestion and for prevention of gastrointestinal cancer. Its beta glucan composition is very similar to some of the most potent anti-cancer mushrooms such as Agaricus blazei. Also, a hot-water extract made from Lion’s Mane is considered a health tonic and sports beverage. In clinical trials with aged disabled patients, Lion’s Mane treatment healed methicillin-resistant Staphylococcus aureus (MRSA) infections (MRSA is a pathogen prevalent in hospital settings). Scientific studies performed in Asia confirm traditional use of Lion’s Mane as a respiratory and nervous system tonic. In particular, Japanese studies show that Lion’s Mane is able to regenerate neurons by stimulating production of Nerve Growth Factor.4

Hericium erinaceus Panthera leo

III. Nerve Growth Factor

Nerve Growth Factor (NGF) belongs to a family of proteins that play a part in maintenance, survival and regeneration of neurons during adult life. As we age, NGF declines, resulting in less efficient brain functioning. In mice, its absence leads to a condition resembling Alzheimer’s disease.

In 1986, two scientists were awarded the Nobel Prize in Physiology/Medicine for the discovery and isolation of NGF. Italian biologist Rita Levi-Montalcini and American biochemist Stanley Cohen won for their groundbreaking work, which opened new fields of widespread importance to basic science. Their work has lead, and continues to lead, to development of new therapeutic agents and improved treatment of various diseases. Now, at the age of 102, Dr. Levi-Montalcini appears to be personally benefiting from her discovery. Her amazing vitality could be due to the fact that she takes NGF in eye drops every day. She admits that her brain is more vigorous today than it was four decades ago.

Dr. Levi-Montalcini

Many clinical trials have shown that NGF can reduce neurodegeneration and has potential to treat diseases of the nervous system. Dr. Will Boggs reported in Neurology magazine that NGF significantly improves pain symptoms of HIV-infected patients with sensory neuropathy. Sensory neuropathy most commonly affects the feet, legs, hands and arms, and affects more than a third of all AIDS patients. Dr. Giovanni Schifitto from the University of Rochester, New York studied the safety and effectiveness of human NGF for HIV-associated distal sensory polyneuropathy in 200 affected patients. Their symptoms were significantly alleviated with the administration of NGF.

NGF has been shown to play a role in a number of diseases, such as coronary atherosclerosis, obesity, type 2 diabetes and metabolic syndrome. NGF could also be related to various psychiatric disorders, such as dementia, depression, schizophrenia, autism, Rett syndrome, anorexia and bulimia. NGF has been shown to accelerate wound healing, and there is evidence it could be useful for treating skin and corneal ulcers.

In 2005, researchers at the University of Pavia, Italy found that people have high levels of NGF when they first fall in love, but that these levels return to former levels after one year. NGF levels of 58 subjects were compared to controls that were either single or presently engaged in a long term relationship. Results showed that NGF levels were significantly higher in subjects in love compared to either control group.

Since the discovery of NGF, researchers have been interested in ways of enhancing NGF. But because it is unable to cross the blood-brain barrier, it cannot be administered as an oral drug. Accordingly, scientists have been directing their attention to finding bioactive compounds with a low molecular weight that could penetrate the blood-brain barrier and be taken orally to induce synthesis of NGF within the brain.

A breakthrough occurred when Hirokazu Kawagishi, Ph.D., discovered a class of compounds in Lion’s Mane that stimulate production of NGF, causing neurons to regrow.5 These compounds, called hericenones, are the first active substances found in natural products to induce NGF synthesis. Hericenones were isolated from the fruiting body of Lion’s Mane and introduced into a culture containing astroglial cells obtained from rats. After 24 hours, an assay revealed that NGF was secreted into the culture medium.

Dr. Hirokazu Kawagishi Dr. Cun Zhuang

Co-inventor of Amycenone

Hericenones and other bioactive substances in Lion’s Mane are believed to have great potential for repairing neurological damage, improving intelligence and reflexes, and, even more significant, preventing and treating Alzheimer’s disease.

NGF doesn’t pass blood-brain barrier, but hericenones do!

 

IV. Amyloid Beta-Peptide

An additional fat-soluble fraction isolated from Lion’s Mane, called amyloban (a fat-soluble fraction containing dilinoleoyl-phosphatidylethanolamine and other active compounds), was found to protect against neuronal cell death caused by toxic amyloid beta-peptide.6 Amyloid beta-peptide is the main component of plaque that develops in the brains of Alzheimer’s disease patients, causing destruction of neurons as it progresses. It is believed that amyloid deposition also increases the risk of cerebral hemorrhagic stroke by causing blood vessels to become brittle and eventually break.

Death of neurons is a feature of neurodegenerative disease, such as Alzheimer’s, Parkinson’s, Huntington’s and prion diseases (Creutzfeldt-Jakob/mad cow disease). Amyloid beta-peptide is a chief offender that induces cellular stress and damages neurons. So, if natural products could reduce cellular stress they would be good candidates for preventing cell death. There are reports that unsaturated fatty acids, like those in fish and plants, exert a protective effect on certain neurodegenerative diseases. However, in most of these, the detailed mechanisms by which protection is afforded have not been resolved.

This is not the case with amyloban as research has identified a chemical pathway as the mechanism. In assays of rat cell viability, researchers found that amyloban protects neurons from endoplasmic reticulum (ER) stress- or oxidative stress-dependent cell death associated with amyloid beta-peptide.

In the course of further extensive screening, researchers found three new active compounds in Lion’s Mane.7 One of these, identified as 3-hydroxyhericenone, showed significant protective activity against chemically-induced ER stress in neural cells.

It should be mentioned here that amyloban and hericenones are not found in all Lion’s Mane products. Because amyloban and hericenones are fat-soluble, they are not contained in Lion’s Mane products extracted by hot water only. Also, there has been no report to suggest that the mycelium (root-like structure) contains hericenones or shows bioactivity like amyloban. The method to concentrate active compounds, which requires ethanol (alcohol) extraction and some fractionations, has been filed for a U.S. patent.8 This is the extract found in the product AMYLOBAN® 3399 (a designation from the Japanese patent number).9

V. Alzheimer’s Disease and Other Types of Dementia

In the United States, we tend to think of all memory related diseases as Alzheimer’s. In reality, it is part of a larger group of symptoms that affect the brain. When we mention dementia it conjures up images of the elderly unable to recall where they are or even what day it is. Both of those concepts are generalized and only scratch the surface of the relationship between the two.

Dementia means “deprived mind,” and is not a disease itself. It is a collection of symptoms that are the result of what occurs to our memory and other cognitive functions due to the damage caused by a disease (i.e. Alzheimer’s, Parkinson’s and Huntington’s). Out of these, Alzheimer’s disease is the leading cause of all forms of dementia.

People who suffer from dementia lose their ability to problem solve and stay in control of their emotions. Their personality can change drastically and they may become more agitated or experience delusions and hallucinations. Dementia develops later in life and roughly 8 percent of people 65 or older have some form of it. Modern science has yet to discover a cure for Alzheimer’s or Parkinson’s, although they claim to have medications that can prevent cognitive function from deteriorating as quickly if left untreated. But it’s important to understand that there are some subtle forms of dementia that aren’t as widely publicized and can, in fact, be treatable.

While we have all heard, read or even lived through stories of the elderly dealing with dementia, it is important to note that it is not a normal part of aging. The association with getting older and developing a brain related disease, at least one that would be caused simply by the aging process, is far too closely tied together.

There are many classifications of dementia and every one of them is the result of the death of nerve cells or the loss of communication between them. Genes and how they interact can also have an effect on whether or not a person develops dementia.

Dementia can be caused by:

#
p<>{color:#000;}. Substance abuse (over long periods of time)

#
p<>{color:#000;}. Vitamin B12 deficiency

#
p<>{color:#000;}. An underactive thyroid

#
p<>{color:#000;}. Hypoglycemia (due to low blood sugar)

#
p<>{color:#000;}. Diseases that affect blood vessels such as stroke

#
p<>{color:#000;}. Infections that affect the brain and spinal cord

#
p<>{color:#000;}. Brain tumors

#
p<>{color:#000;}. Severe head injuries or long term smaller injuries

#
p<>{color:#000;}. Illnesses dealing with the kidney, liver or lungs

Alzheimer’s disease (AD) is a condition in which brain cells degenerate and die, causing a steady decline in memory and mental function. About one in ten people over age sixty-five are diagnosed with the condition. If trends continue, half of those who make it into their eighties will contract AD, and the number of cases could quadruple by year 2050. But AD is not just a disease of old age. Up to 5 percent of people with the disease have early onset Alzheimer’s (also known as younger-onset), which often appears when someone is in their 40s or 50s. Those with Alzheimer’s live an average of eight years after their symptoms become noticeable to others, but survival can range from four to 20 years, depending on age and other health conditions.

Presently, there is no cure for AD, and conventional treatments only address the symptoms of the disease. Scientific studies suggest relationships between certain modifiable factors and a person’s likelihood of developing AD. These factors include diet, stress, cardiovascular disease risk and intellectual activities among others. The components of a traditional Mediterranean diet, which include fruit and vegetables, grains, olive oil, fish, and red wine, may all individually or collectively reduce the risk and course of AD.

It is now known that amyloid beta-peptide begins to accumulate in the brain ten to fifteen years before onset of dementia. Since NGF has been suggested as a treatment for AD, compounds in Lion’s Mane are attracting great attention for preventing and treating various types of dementia. An effective way to reduce the risk of AD and other types of dementia might be the daily intake of foods or dietary supplements that stimulate NGF and inhibit toxicity of beta amyloid beta-peptide.

Alzheimer’s Association 10 Warning Signs of Alzheimer’s Disease

#
p<>{color:#000;}. Memory loss that disrupts daily life

#
p<>{color:#000;}. Challenges in planning or solving problems

#
p<>{color:#000;}. Difficulty completing familiar tasks at home, at work or at leisure

#
p<>{color:#000;}. Confusion with time or place

#
p<>{color:#000;}. Trouble understanding visual images and spatial relationships

#
p<>{color:#000;}. New problems with words in speaking or writing

#
p<>{color:#000;}. Misplacing things and losing the ability to retrace steps

#
p<>{color:#000;}. Decreased or poor judgment

#
p<>{color:#000;}. Withdrawal from work or social activities

#
p<>{color:#000;}. Changes in mood or personality

VI. Anti-Dementia Studies

Effects of a Proprietary Lion’s Mane Extract

A study at a Chinese Pharmaceutical University compared AmycenoneTM, a Lion’s Mane extract standardized to contain hericenones (0.5%) and amyloban (6%), with donepezil, a common Alzheimer’s drug (Aricept).10 (Amycenone™ is the standardized extract developed by Mushroom Wisdom, Inc. as a raw material. AMYLOBAN® 3399 is the finished product in tablet form.) In the experiment, one hundred rats were injected with amyloid beta-peptide to create an Alzheimer’s type dementia. Twenty rats received a sham operation using a saline solution to serve as controls. The rats were then divided into groups to receive either Lion’s Mane extract or the drug once a day for four weeks. At the fourth week, an assessment of learning and memory related behavior was made for six consecutive days using Morris Water Maze test.

The test consists of a pool of water in which the rats must swim. In a small part of the pool, a hidden escape platform is placed just below the water surface. The rats swim around the pool in search of an escape. Time is recorded to measure how long it takes them to learn the position of the platform. With subsequent trials, the rat is able to locate the platform more rapidly. After enough practice, a capable rat can swim directly from any release point to the platform.

Results of the water maze test showed that rats injected with amyloid beta-peptide spent a significantly longer time arriving at the platform compared to the healthy controls, demonstrating that the dementia model was successfully created. In the groups receiving donepezil or Lion’s Mane extract, arrival time to the platform was significantly shorter compared to rats that did not receive either treatment. Furthermore, the rats treated with the Lion’s Mane extract performed the water maze test equal or better to the Alzheimer’s drug, depending on dosage of the extract.

After completing the behavioral test, all rats were sacrificed for pathological examination to determine the NGF content in the brain. It was found that rats who received Lion’s Mane extract produced significantly more NGF.

Preliminary Clinical Study with Dementia Patients

A clinical study using Lion’s Mane was conducted in a rehabilitative hospital in Japan to investigate its effectiveness against dementia.11 The study consisted of 50 patients in the experimental group (average age 75) and 50 controls (average age 77). Seven of the patients in the experimental group suffered from different types of dementia. The patients in this group received 5 grams of dried mushroom per day in their soup for a six month period. All patients were evaluated before and after the treatment period for their Functional Independence Measure (FIM), which is an international evaluation standard of independence in physical capabilities (eating, dressing, evacuating, walking, bathing/showering, etc.) and in perceptive capabilities (understanding, expression, communication, problem-solving, memory).

Results showed that after six months of taking Lion’s Mane, six out of seven patients experienced improvements in their perceptual capacities, and all seven had improvements in their overall FIM score. In particular, three bedridden patients were able to get up to eat meals after administration. These results are very encouraging, and more extensive clinical studies are currently underway at other hospitals.

The effect of Lion’s Mane treatment on the perception part of the Functional Independence Measure score

 

 

The effect of Lion’s Mane treatment on the total Functional Independence Measure score

Clinical Trial with Alzheimer’s Disease Patients

Eighteen Alzheimer’s disease patients ranging in age from 64 to 87 were given 1.5 grams of powdered Lion’s Mane twice a day after breakfast and supper for three months.12 Patients’ cognitive function was assessed before and after administration with the Mini-Mental State Examination, a brief 30-point questionnaire commonly used to screen for dementia. The test is also used to estimate the severity of cognitive impairment at a given point in time and to follow the course of cognitive changes in an individual over time, thus making it an effective way to document an individual’s response to treatment. Any score over 27 (out of 30) is effectively normal. Below this, 20-26 indicates some cognitive impairment; 10-19 moderate to severe impairment, and below 10 very severe impairment.

At the end of the trial, 9 patients (50 percent) improved their scores. In 7, there was no change, and 2 performed worse. Of the 9 patients that improved, three were re-classified from moderate cognitive impairment to some cognitive impairment.

 

VII. Cognitive Studies

Clinical Trial for Cognitive Impairment

A double-blind, placebo-controlled study, demonstrated that Lion’s Mane is effective in patients diagnosed with mild cognitive impairment.13 A group of thirty Japanese men and women ages 50 to 80 were randomized into two 15-person groups, one of which was given Lion’s Mane and the other a placebo. The subjects in the Lion’s Mane group took four 250 milligram tablets containing dry powder three times per day for sixteen weeks. At weeks 8, 12, and 16 of the trial, the Lion’s Mane group showed significantly increased scores on a cognitive function scale compared with the placebo group.

The assessment was made using the revised Hasegawa Dementia Scale, the preferred test in Asian countries for subjective verification before and after treatment. It is considered more accurate for assessing cognitive impairment than a Western version, which screens for Alzheimer’s disease in elderly psychiatric patients. At the end of the trial, 10 subjects in the Lion’s Mane group were notably improved with one unchanged compared to one in the placebo group improved and thirteen cases unchanged. It is important to note that scores of the Lion’s Mane group increased with the duration of intake. However, four weeks after terminating the supplement the scores decreased significantly, indicating that cognitive benefits are maintained only with continuous administration of Lion’s Mane.

Score of Cognitive Function Scale

 

Clinical Trial for Cognitive Enhancement

A 2-month clinical trial with 8 volunteers was conducted by Elisa Lottor, Ph.D., N.D. at Pacifica Women’s Health, Oxnard, California to demonstrate the cognition-enhancing properties of Amyloban® 3399, and measure the levels of acceptance and improvement by participants.14 Age of the participants ranged from 58 to 72. Volunteers were excluded if they had been on any cognition-enhancing medications. Two variables were measured: memory improvement and mood. Also, tolerance was tested by having participants take Amyloban® 3399 one pill three times per day with food for the first month and then increase to two pills three times per day for the second month. Patients agreed to take a self-administered questionnaire at the beginning of the study and the same one at the end. Additionally, patients were orally interviewed at the end of the study.

Amyloban was generally well tolerated. Two participants reported feeling “more upbeat,” “optimistic” and “energetic.” Two noticed marked difference when dosage increased to six per day. One noticed she felt really focused on being organized, and finished one task before beginning another. She reported being a lot less scattered and more disciplined. Those who experienced the greatest improvement in cognition, mood and general sense of well-being were not on any prescription medication such as statins, hypertensive drugs or blood thinners. Overall results of the study showed that Amyloban® 3399 improved mood, memory and sense of well-being in 100 percent of those who were medication free. The study also suggests that Amyloban® 3399 has excellent potential for the majority of the population.

 

VIII. Depression and Anxiety

Researchers at the Department of Clinical Psychology, Kyoto, Japan investigated the clinical effects of Lion’s Mane on menopause, depression, sleep quality and indefinite complaints.15 Thirty females were randomly assigned to either a Lion’s Mane or placebo group for four weeks. The Lion’s Mane group received a cookie containing 0.5 grams of the powdered fruiting body whereas the placebo received a cookie containing no powder. Participants were instructed to eat eight cookies at any time per day.

Of the thirty participants, 26 completed the trial and their data were analyzed. It was found the Lion’s Mane group had improved scores. The mean menopausal index score, depression scale and indefinite complaints index score after the trial was significantly lower than that before. In the indefinite complaints index, the terms “incentive” and “concentration” were relevant to depression, and the term “anxious” was relevant to anxiety. In the sleep quality index score, there was no significant difference between the two groups before and after the trial.

Results show that Lion’s Mane intake has the potential to reduce depression and anxiety. Researchers speculated that a different mechanism other than NGF stimulation might also be at work.

IX. Sleep Apnea and Snoring

A small study was conducted by Kazutoyo Inanaga, M.D., Professor Emeritus, Kurume University and director of the Chikusuikai Institute for Neuroinformation, Fukuoka, Japan to evaluate Amyloban® 3399 in patients suffering from sleep apnea syndrome, a condition in which breathing becomes very shallow and may even stop.16 The condition affects more than 12 million Americans, and episodes can happen hundreds of times during a night. Sleep apnea can be disastrous for brain function. Amyloid beta plaque can accumulate when a person becomes sleep deprived. Scientific data suggest that those suffering from neurodegeneration often have severe sleep disorders that may develop before any memory related issues are noticed.

In the study, nine patients took six tablets of Amyloban® 3399 per day in divided doses for two months. In addition to sleep apnea syndrome, seven subjects suffered from high blood pressure, one from bipolar disorder, and another from dysthymia, a mild but chronic form of depression. During the observation period, no changes were made to the prescriptions of subjects, who were taking various other medications. Shallow breathing, oxygen utilization and snoring were all monitored with mobile sleep devices before, during and at the end of the study.

After one month, researchers observed significant improvements overall and a slight decrease in the average snoring index. At two months, snoring and oxygen utilization improved further, and shallow breathing in three patients progressed to normal. One diagnosed with severe shallow breathing improved to moderate.

Sleep apnea has emerged as a serious threat to health and longevity, and research has linked it to high blood pressure, heart disease, stroke, diabetes, irregular heartbeats, depression and even cancer. Recent studies reported in major medical journals have produced compelling evidence that sleep apnea also contributes to cognitive decline and dementia by causing a drop in the level of oxygen in the blood.

A study at the University of California followed 298 older women who were free of cognitive problems. Slightly more than one-third of the women had sleep-disordered breathing. Over five years, nearly 45 percent of those women developed mild cognitive impairment or dementia compared to only 31 percent of the women without sleep problems. Another study found that 17 patients who were not treated for sleep apnea displayed impairments in cognition and mood associated with brain shrinkage in areas associated with memory. After continuous positive airway treatment, those areas increased in volume, and the patients displayed improvements in memory, attention and planning.

Sound sleep is essential to good health. Its primary function is to refresh the brain. If Amyloban® 3399 can improve sleep apnea it could translate to better overall health. The positive results obtained by Dr. Inanaga suggest that Amyloban® 3399 might be useful on its own or as a compliment to conventional treatment.

At the time this book went to press, Dr. Inanaga was starting clinical studies with Parkinson’s disease and schizophrenia patients. In preliminary cases so far, he has observed good results with Amyloban® 3399.

 

X. Case Studies^17^

[++
An 81-Year-Old Female with Dementia]

Individual case studies provided by doctors, patients and families are also very encouraging. For example, an 81-year-old female diagnosed with dementia suffered from anxiety, insecurity and aggression for eight years. Prescribed medications had to be discontinued as the patient had not responded well to them. It was only after starting on Amyloban® 3399 that her husband observed significant improvements after about two months. He noticed that she was able to cook more often and easily name vegetables. She was also able to sleep more peacefully. In an interview, her disposition seemed calm and comfortable. During a medical examination, she achieved a perfect score on a word-finding test, whereas she used to make more than ten mistakes. Also, her score on the Hasegawa Dementia Scale, which had not shown significant improvement in the last four years, showed a change. Previously, she scored 20-22, but now scored 29, a remarkable improvement.

 

A 41-Year-Old Male with Early Onset Dementia

Another case was that of a 41-year-old business man. Despite his relatively young age, he began experiencing hand tremors and noticed that he was forgetting appointments and conversations with employees. As symptoms became worse he decided to get a medical evaluation and was diagnosed with early-onset dementia. As fate would have it, he had a chance meeting with an old college friend who worked for a large pharmaceutical company. During their discussion, the friend informed him about Alzheimer’s medications and Lion’s Mane extract. After careful consideration, the business man made a decision to try the natural mushroom extract. After three to four months, the hand tremors disappeared and his concentration and retention gradually improved. After six months, he was able to recall complete agendas, not only for the week but also from the week before.

 

An 88-Year-Old Male with Dementia

A retired 88-year-old Japanese man suffered from dementia for two years. During this time he admits remembering nothing. But his family does. His wife first began to notice signs of encroaching dementia when he was 85. It began with small things such as forgetting what he said or what was told to him. The memory loss became more serious as he became less able to recall situations that occurred only minutes prior. The family began extensive research hoping to find some sort of cure, or at least something that would improve his symptoms. They were then introduced to Amyloban® 3399, and the patient started taking two tablets three times per day. Changes were noted after just a few months. His demeanor changed as he began to look more alive. The patient experienced a full recovery after two years of memory loss, which he attributes to Amyloban® 3399.

 

A 79-Year-Old Female with Drug-Induced Mild Cognitive Disorder

A 79-year-old woman had complained of insomnia and severe tinnitus for more than a year. She was prescribed a hypnotic and several other medications in three hospitals without improvement. In early 2011, she started to complain of forgetfulness, staggering walk and loss of personal items. Her family informed doctors that she was increasingly irritated and that her eyes were vacant. At this time she was taking three different medications. She then visited the Chikusuikai clinic where she was diagnosed with early stage dementia or drug-induced cognitive decline. The patient was ordered to discontinue previously prescribed medications and was informed with family of potential for treatment with Amyloban® 3399. Consequently, she agreed to take two tablets three times per day (six tablets per day). Ten days after initiation of treatment, the patient informed the clinic that she felt very clear-headed and no longer light-headed but was only able to sleep 4 or 5 hours. At this point, she decided to reduce the dosage to three tablets per day. Approximately two months later, she reported she was sleeping 7-1/2 hours but still awoke periodically throughout the night. The patient was advised to go back on a dose of six tablets per day along with ramelteon, a melatonin receptor agonist. One month later, she was sleeping well but still complained of tinnitus. She was then prescribed duloxetine, an antidepressant, to treat the tinnitus. Another thirty days passed and her family reported that she had improved. Testing confirmed that behavioral and psychological symptoms improved completely.

 

XI. Summary

Can a healthful diet and supplementation improve alertness, memory and intelligence? Skeptics say it’s impossible to exceed the normal capabilities of the well-nourished brain. Others believe that we use only a fraction of our brain potential, and that there are no limits to the human mind. Most of us experience a sort of brain fog now and then. At other times, focus and creativity can be exceptionally high. Researchers tell us that the brain is more sensitive to what we eat and what pills we swallow than any other organ. Usually, it’s the first organ to feel the effects of what we eat.

Cancer patients receiving chemotherapy often experience brain fog. Some cancer patients refer to the forgetfulness or inability to concentrate as “chemobrain.” How chemotherapy might cause cognitive deficits is not clear at this time.

To perform at its best, the brain requires an assortment of nutrients such as B vitamins and omega-3 fatty acids, along with a steady supply of glucose (blood sugar) and oxygen. If the blood sugar level drops, we might feel irritable or depressed, crave sweets, or have difficulty concentrating.

Although only 5 percent of the body’s weight, the brain consumes 20 percent of the blood supply. To meet this demand, a healthy circulatory system is critical for delivering all vitamins and other essential nutrients contained in blood. Circulation is a key issue in most diseases of aging.

Older individuals often talk about having a “senior moment.” The fact is, at least 2 of every 5 individuals who have reached age 55 have memory loss serious enough to hold them back in their daily lives. More troubling, half of those who make it into their 80s will be diagnosed with Alzheimer’s disease, now the sixth leading cause of death in the United States. Surveys show that it is the most feared disease after cancer.

Smart drugs, cognitive enhancers and nootropics are emerging whereby cognition and memory are enhanced in healthy, normal individuals as well as those suffering from cognitive deficits of one kind or another. After hundreds of years of use and promising research, a growing number of health professionals and consumers are turning to Lion’s Mane and Amyloban® 3399 as a natural means to slow down and even reverse symptoms of declining cognitive function and sensory neuropathy. With continual usage, Amyloban® 3399 may also prove to be effective for sleep apnea. As the numbers of sufferers needing some type of NGF therapy climbs, and with no cure in sight from conventional medicine, many people are using Amyloban® 3399 to stimulate the body’s own production of NGF.

We recommend a Lion’s Mane supplement derived from the fruiting body of the mushroom for maintenance and prevention in healthy individuals. It also makes an excellent choice as a digestive and immune system tonic. Amyloban® 3399, on the other hand, is the product of choice for therapeutic brain and nerve support. Because amyloban and hericenones are fat-soluble, they are not contained in products extracted with hot water only. Concentration of active compounds requires a special method utilizing ethanol extraction and some fractionations. This is the extract found in Amyloban® 3399.

 

References

1. Soares, R. et al Maitake (D Fraction) Mushroom Extract Induces Apoptosis in Breast Cancer Cells by BAK-1 Gene Activation, Journal of Medicinal Food 14(6),563-572,2011

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The Power of the Lion's Mane Mushroom: Regenerate Your Brain With Lion's Mane

The Lion's Mane Mushroom has been nicknamed the "Gift of God" and for pretty good reasons. This is the brain mushroom. The secret to this amazing medicinal mushroom is its ability to improve nerve growth factor in the brain. Nerve Growth Factor (NGF) belongs to a family of proteins that play a part in maintenance, survival and regeneration of neurons during adult life. As we age, NGF declines, resulting in less efficient brain functioning. In mice, its absence leads to a condition resembling Alzheimer's disease. Nerve Growth Factor has been shown to play a role in a number of diseases, such as coronary atherosclerosis, obesity, type 2 diabetes and metabolic syndrome. NGF could also be related to various psychiatric disorders, such as dementia, depression, schizophrenia, autism, Rett syndrome, anorexia and buliminia. NGF has been shown to accelerate wound healing, and there is evidence it could be useful for treating skin and corneal ulcers.

  • ISBN: 9781370025848
  • Author: Ward W. Bond Ph.D.
  • Published: 2017-05-30 19:35:14
  • Words: 6166
The Power of the Lion's Mane Mushroom: Regenerate Your Brain With Lion's Mane The Power of the Lion's Mane Mushroom: Regenerate Your Brain With Lion's Mane